Chuck Abbott, “Arkansas Task Force Aims for Long-Term Recommendations on Use of Dicamba,” The Fern, August 9, 2017.
Arkansas has appointed a 21-member task force to help identify solutions for the dicamba drift damage problem, with 900 complaints received this year so far. FULL TEXT
Acquavella JF, Alexander BH, Mandel JS, Gustin C, Baker B, Chapman P, Bleeke M, “Glyphosate biomonitoring for farmers and their families: results from the Farm Family Exposure Study.” Environmental Health Perspectives, 2004, 112:3.
ABSTRACT: Glyphosate is the FULL TEXTin Roundup agricultural herbicides and other herbicide formulations that are widely used for agricultural, forestry, and residential weed control. As part of the Farm Family Exposure Study, we evaluated urinary glyphosate concentrations for 48 farmers, their spouses, and their 79 children (4-18 years of age). We evaluated 24-hr composite urine samples for each family member the day before, the day of, and for 3 days after a glyphosate application. Sixty percent of farmers had detectable levels of glyphosate in their urine on the day of application. The geometric mean (GM) concentration was 3 , the maximum value was 233 ppb, and the highest estimated systemic dose was 0.004 mg/kg. Farmers who did not use rubber gloves had higher GM urinary concentrations than did other farmers (10 ppb vs. 2.0 ppb). For spouses, 4% had detectable levels in their urine on the day of application. Their maximum value was 3 ppb. For children, 12% had detectable glyphosate in their urine on the day of application, with a maximum concentration of 29 ppb. All but one of the children with detectable concentrations had helped with the application or were present during herbicide mixing, loading, or application. None of the systemic doses estimated in this study approached the U.S. Environmental Protection Agency reference dose for glyphosate of 2 mg/kg/day. Nonetheless, it is advisable to minimize exposure to pesticides, and this study did identify specific practices that could be modified to reduce the potential for exposure.
Adams, A, Friesen, M, Olson, A, Gerona, R. “Biomonitoring of glyphosate across the United States in urine and tap water using high-fidelity LC-MS/MS method,” 2016. Poster presentation, access at: http://cehn-healthykids.org/wp-content/uploads/2017/02/APAMT-Poster-Gerona.pdf.
Agopian AJ, Lupo PJ, Canfield MA, Langlois, “ of maternal residential atrazine exposure and male genital malformations,” American Journal of Medical Genetics Part A, 2012, 161A:5, doi: 10.1002/ajmg.a.35815.
ABSTRACT: Exposure to endocrine disrupting chemicals has been associated with risk for male genital malformations. However, residential prenatal exposure to atrazine, an endocrine disrupting pesticide, has not been evaluated. We obtained data from the Texas Birth Defects Registry for 16,433 cases with isolated male genital malformations and randomly selected, population-based controls delivered during 1999-2008. County-level estimates of atrazine exposure from the United States Geological Survey were linked to all subjects. We evaluated the relationship between estimated maternal residential atrazine exposure and risk for male genital malformations in offspring. Separate unconditional logistic regression analyses were conducted for hypospadias, cryptorchidism, and small penis. We observed modest, but consistent, associations between medium-low and/or medium levels of estimated periconceptional maternal residential atrazine exposure and every male genital malformation category evaluated (e.g., adjusted odds ratio for medium compared to low atrazine levels and all male genital malformations: 1.2, 95% confidence interval: 1.1-1.3). Previous literature from animal andsupports our findings. Our results provide further evidence of a suspected teratogenic role of atrazine.
Anway, Matthew D., Cupp, Andrea S., Uzumcu, Mehmet, and Skinner, Michael K., “Transgenerational Actions of Endocrine Disruptors and Male Fertility,” Science, 2005, 308:5727, DOI: 10.1126/SCIENCE.1108190.
Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult FULL TEXTin the F1 generation of decreased spermatogenic capacity (cell number and viability) and increased incidence of male infertility. These effects were transferred through the male germ line to nearly all males of all subsequent generations examined (that is, F1 to F4). The effects on reproduction correlate with altered DNA patterns in the germ line. The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease .
Arbuckle TE, Savitz DA, Mery LS, Curtis KM, “Exposure to phenoxy herbicides and the risk of spontaneous abortion,” Epidemiology, 1999, 10:6.
ABSTRACT: The Ontario Farm Family Health Study was designed to assess retrospectively the potential adverse effects of exposure to pesticides on pregnancy. Information on the health and life style of approximately 2,000 farm couples, as well as a history of use of pesticides on the farm, was collected by questionnaire. This analysis focuses on pre- and postconception exposure to phenoxy herbicides and the risk of spontaneous abortion using the complete (to date) pregnancy history for each woman. Preconception exposure (from 3 months before conception to the month of conception) was weakly associated with the risk of spontaneous abortion at <20 weeks’ gestation [adjusted odds ratio (OR) = 1.1; 95% confidence interval (CI) = 0.6-1.9]. When the analyses were restricted to spontaneous abortions of <12 weeks, the risk was more than doubled (adjusted OR = 2.5; 95% CI = 1.0-6.4), but the results were sensitive to the cutpoint used. If the husband did not normally wear protective equipment during application, the crude OR for early spontaneous abortions was 5.0 (95% CI = 0.7-36.2). Exposure to phenoxy herbicides during the first trimester was generally not associated with increased risk of spontaneous abortion. The results suggest a possible role of preconception (possibly paternal) exposures to phenoxy herbicides in the risk of early spontaneous abortions.
Arbuckle TE, Lin Z, Mery LS., “An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population,” Environmental Health Perspectives, 2001, 109: 8.
ABSTRACT: The toxicity of pesticides on human reproduction is largely unknown–particularly how mixtures of pesticide products might affect fetal toxicity. The Ontario Farm Family Health Study collected data by questionnaire on the identity and timing of pesticide use on the farm, lifestyle factors, and a complete reproductive history from the farm operator and eligible couples living on the farm. A total of 2,110 women provided information on 3,936 pregnancies, including 395 spontaneous abortions. To explore critical windows of exposure and target sites for toxicity, we examined exposures separately for preconception (3 months before and up to month of conception) and postconception (first trimester) windows and for early (< 12 weeks) and late (12-19 weeks) spontaneous abortions. We observed moderate increases in risk of early abortions for preconception exposures to phenoxy acetic acid herbicides [odds ratio (OR) = 1.5; 95% confidence interval (CI), 1.1-2.1], triazines (OR = 1.4; 95% CI, 1.0-2.0), and any herbicide (OR = 1.4; 95% CI, 1.1-1.9). For late abortions, preconception exposure to glyphosate (OR = 1.7; 95% CI, 1.0-2.9), thiocarbamates (OR = 1.8; 95% CI, 1.1-3.0), and the miscellaneous class of pesticides (OR = 1.5; 95% CI, 1.0-2.4) was associated with elevated risks. Postconception exposures were generally associated with late spontaneous abortions. Older maternal age (> 34 years of age) was the strongest risk factor for spontaneous abortions, and we observed several interactions between pesticides in the older age group using Classification and Regression Tree analysis. This study shows that timing of exposure and restricting analyses to more homogeneous endpoints are important in characterizing the reproductive toxicity of pesticides. FULL TEXT
Ludmilla Aristilde, Michael L. Reed, Rebecca A. Wilkes, Tracy Youngster, Matthew A. Kukurugya, Valerie Katz, and Clayton R. S. Sasaki, “Glyphosate-Induced Specific and Widespread Perturbations in the Metabolome of Soil Pseudomonas Species,” Frontiers in Environmental Science, 2017, 5:34, DOI: 10.3389/fenvs.2017.00034.
Previous studies have reported adverse effects of glyphosate on crop-beneficial soil bacterial species, including several soil Pseudomonas species. Of particular interest is the elucidation of the metabolic consequences of glyphosate toxicity in these species. Here we investigated the growth and metabolic responses of soil Pseudomonas species grown on succinate, a common root exudate, and glyphosate at different concentrations. We conducted our experiments with one agricultural soil isolate, P. fluorescens RA12, and three model species, P. putida KT2440, P. putida S12, and P. protegens Pf-5. Our results demonstrated both species- and strain-dependent growth responses to glyphosate. Following exposure to a range of glyphosate concentrations (up to 5 mM), the growth rate of both P. protegens Pf-5 and P. fluorescens RA12 remained unchanged whereas the two P. putida strains exhibited from 0 to 100% growth inhibition. We employed a 13C-assisted metabolomics approach using liquid chromatography-mass spectrometry to monitor disruptions in metabolic homeostasis and fluxes. Profiling of the whole-cell metabolome captured deviations in
lethal dose of glyphosate completely recovered in terms of both growth rate and selected metabolite levels. Collectively, our findings led us to conclude that the glyphosateinduced specific disruption of de novo biosynthesis of aromatic AAs accompanied by widespread metabolic disruptions was responsible for dose-dependent adverse effects of glyphosate on sensitive soil Pseudomonas species. FULL TEXT
Associated Press, “Arkansas governor approves board’s limits on dicamba use,” The Washington Times, January 4, 2017.
Reports that Gov. Hutchinson has approved the Arkansas State Plant Board’s proposal to limit when and where dicamba can be sprayed in the upcoming planting season. It includes a requirement for a 1 mile buffer zone before spraying dicamba, except on pasture or rangeland. FULL TEXT
Associated Press, “Farm chemical linked to oak damage,” July 2, 2017, Quad-City Times,
Reports that almost 1,000 residents of Iowa have contacted the state Department of Natural Resources about damaged leaves on oak trees (photo, right) that looked like insect damage. Research from the University of Illinois in 2004 showed that herbicide drift was likely linked to the condition, known as leaf tatters, due to exposure to chloroacetanilide herbicides like dicamba. Exposure occurs from direct drift but also through atmospheric volubility in areas not close to where the herbicide was applied. White oaks are particularly susceptible, and trees can die if damage to the leaves occurs over multiple years. FULL TEXT